Browsing by Author "Morales Ledesma, Leticia; 0000-0002-5276-8260"

Now showing 1 - 3 of 3
  • Artículo
    Polycystic ovary syndrome induced by exposure to testosterone propionate and effects of sympathectomy on the persistence of the syndrome
    (2017-07-10) Morales Ledesma, Leticia; Díaz Ramos, Juan Antonio; Trujillo Hernández, Angélica; Morales Ledesma, Leticia; 0000-0002-5276-8260; Trujillo Hernández, Angélica; 0000-0002-9931-9294
    "Polycystic ovary syndrome is a complex disorder affecting 6 to 10% of women of reproductive age. In recent years, the cause of the syndrome has been associated with increased androgen serum levels, as well as sympathetic nervous system hyperactivity. The present study analyzed the effects at birth of a single testosterone propionate dose in rats, as well as the role of the superior ovarian nerve in polycystic ovary syndrome persistence. Newborn female rats of the CIIZV strain were injected with a single dose of 100 μg testosterone propionate, or corn oil as a vehicle. At 24 days of age, rats were subjected to superior ovarian nerve unilateral or bilateral section. A group of animals was sacrificed on their first vaginal estrus, and a second group was sacrificed at 90 days of age, when they presented an estrus preceded by a proestrus".
  • Artículo
    The neural signals of the superior ovarian nerve modulate in an asymmetric way the ovarian steroidogenic response to the vasoactive intestinal peptide
    (2018-08-20) Rosas, Gabriela; Linares, Rosa; Ramírez, Deyra A.; Vieyra Valdez, Elizabeth; Trujillo Hernández, Angélica; Domínguez, Roberto; Morales Ledesma, Leticia; Linares, Rosa; 0000-0002-5575-4120; Vieyra Valdez, Elizabeth; 0000-0001-9413-4808; Trujillo Hernández, Angélica; 0000-0002-9931-9294; Morales Ledesma, Leticia; 0000-0002-5276-8260
    "The superior ovarian nerve (SON) provides neuropeptide-Y, norepinephrine and vasoactive intestinal peptide (VIP) to the ovaries. Ovarian steroidogenesis is modulated by the SON. In the cyclic rat, the acute steroidogenic response to ovarian microinjection of VIP is asymmetric and varies during the estrous cycle. In the present study, we analyze whether the differential effects of VIP in each ovary are modulated by the neural signals arriving through the SON. Cyclic female rats were submitted on diestrus-1, diestrus-2, proestrus, or estrus to a unilateral section of the SON, and immediately afterward, the denervated ovary was either microinjected or not with VIP. Animals were sacrificed 1 h after treatment. The injection of VIP into the left denervated ovary performed on diestrus-1 decreased progesterone levels in comparison with the left SON sectioning group; similar effects were observed on proestrus when VIP was injected into either of the denervated ovaries".
  • Artículo
    Unilateral section of the superior ovarian nerve induces first ovulation in the Zucker fatty (fa/fa) rat
    (2021-01-01) Puga y Colmenares, María Concepción; Trujillo Hernández, Angélica; Morales Ledesma, Leticia; Trujillo Hernández, Angélica; 0000-0002-9931-9294; Morales Ledesma, Leticia; 0000-0002-5276-8260
    "Hyperactivity in the sympathetic nervous system has been shown to be related to the development of ovarian pathologies. In addition, obesity has been found to be associated with multiple reproductive anomalies and is considered a chronic stress condition of low intensity with changes in the peripheral sympathetic activity. Therefore, in the present study, we aimed to evaluate if the information reaching the ovaries through the superior ovarian nerve (SON) modifies the ovarian function of Zucker fatty rats. We performed a unilateral section of the SON at 32 days of age and autopsies were carried out on the day of the first vaginal estrus. The results showed that fatty animals do not ovulate on the day of the first vaginal estrus and exhibit an increase in catecholaminergic fibers and the presence of precystic structures in the ovaries, without changes in the onset of puberty or in the secretion of ovarian and hypophyseal hormones. We also found that the section of the right SON resulted in ovulation on the day of the first vaginal estrus, which was accompanied by a decrease in ovarian noradrenaline content. The section of the left SON caused a delay in puberty without changes in the rest of the parameters".