Browsing by Author "Gonzalez Mejia, M Elba"

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  • Artículo
    Obese first-degree relatives of patients with type 2 diabetes with elevated triglyceride levels exhibit increased β-cell function
    (2015-02-13) Torres Rasgado, Enrique; Porchia, Leonardo Martín; Ruiz Vivanco, Guadalupe; Gonzalez Mejia, M Elba; Baez Duarte, Blanca Guadalupe; Pulido Pérez, Patricia; Rivera, Alicia; Romero, Jose R; Pérez Fuentes, Ricardo; Torres Rasgado, Enrique; 0000-0001-5273-4522; Porchia, Leonardo Martín; 0000-0002-4082-7606; Ruiz Vivanco, Guadalupe; 0000-0001-5685-3860; Baez Duarte, Blanca Guadalupe; 0000-0002-2311-8605
    "Type 2 diabetes mellitus (T2DM) is characterized as a disease continuum that is marked by metabolic changes that are present for several years, sometimes well before frank diagnosis of T2DM. Genetic predisposition, ethnicity, geography, alterations in BMI, and lipid profile are considered important markers for the pathogenesis of T2DM through mechanisms that remain unresolved and controversial. The aim of this study was to investigate the relationship between triglycerides (TGs) and β-cell function, insulin resistance (IR), and insulin sensitivity (IS) in obese first-degree relatives of patients with T2DM (FDR-T2DM) among subjects from central Mexico with normal glucose tolerance (NGT). Methods: We studied 372 FDR-T2DM subjects (ages,18-65) and determined body mass index (BMI), fasting plasma glucose (FPG), oral glucose tolerance test (OGTT), insulin, and TGs levels. Subjects were categorized based on glycemic control [NGT, prediabetes (PT2DM), or T2DM]. NGT subjects were further categorized by BMI [normal weight (Ob-) or obese (Ob+)] and TGs levels (TG-, <150 mg/dL, or TG+, ≥150 mg/dL). β-cell function, IR, and IS were determined by the homeostasis model assessment of β-cell function (HOMA2-β), homeostasis model assessment of insulin resistance (HOMA2-IR), and Quantitative Insulin Sensitivity Check Index (QUICKI) indices, respectively".