Metallothionein-1 and nitric oxide expression are inversely correlated in a murine model of Chagas disease

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dc.audiencegeneralPublices_MX
dc.contributor.authorGonzalez Mejia, Martha Elba
dc.contributor.authorTorres Rasgado, Enrique
dc.contributor.authorPorchia, Leonardo Martín
dc.contributor.authorRosas Salgado, Hilda
dc.contributor.authorTotolhua, José Luis
dc.contributor.authorOrtega, Arturo
dc.contributor.authorHernández Kelly, Luisa Clara Regina
dc.contributor.authorRuiz Vivanco, Guadalupe
dc.contributor.authorBaez Duarte, Blanca Guadalupe
dc.contributor.authorPérez Fuentes, Ricardo
dc.creatorGonzalez Mejia, Martha Elba; 0000-0003-2569-1998
dc.creatorTorres Rasgado, Enrique; 0000-0001-5273-4522
dc.creatorPorchia, Leonardo Martín; 0000-0002-4082-7606
dc.creatorBaez Duarte, Blanca Guadalupe; 0000-0002-2311-8605
dc.date.accessioned2023-02-07T17:27:32Z
dc.date.available2023-02-07T17:27:32Z
dc.date.issued2014-04
dc.description.abstract"Chagas disease, caused by Trypanosoma cruzi, represents an endemic among Latin America countries. The participation of free radicals, especially nitric oxide (NO), has been demonstrated in the pathophysiology of seropositive individuals with T. cruzi. In Chagas disease, increased NO contributes to the development of cardiomyopathy and megacolon. Metallothioneins (MTs) are efficient free radicals scavengers of NO in vitro and in vivo. Here, we developed a murine model of the chronic phase of Chagas disease using endemic T. cruzi RyCH1 in BALB/c mice, which were divided into four groups: infected non-treated (Inf), infected N-monomethyl-L-arginine treated (Inf L-NAME), non-infected L-NAME treated and non-infected vehicle-treated. We determined blood parasitaemia and NO levels, the extent of parasite nests in tissues and liver MT-I expression levels. It was observed that NO levels were increasing in Inf mice in a time-dependent manner. Inf L-NAME mice had fewer T. cruzi nests in cardiac and skeletal muscle with decreased blood NO levels at day 135 post infection. This affect was negatively correlated with an increase of MT-I expression (r = -0.8462, p < 0.0001). In conclusion, we determined that in Chagas disease, an unknown inhibitory mechanism reduces MT-I expression, allowing augmented NO levels".es_MX
dc.identifierhttps://www.scielo.br/j/mioc/a/4XjNm6nqygv599R64hBRSsF/?lang=en
dc.identifier.urihttps://hdl.handle.net/20.500.12371/17390
dc.language.isoenges_MX
dc.rights.accesopenAccesses_MX
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0es_MX
dc.subject.otherMetallothionein-Ies_MX
dc.subject.otherAntioxidantses_MX
dc.subject.otherNitric oxidees_MX
dc.subject.otherL-NAMEes_MX
dc.subject.otherChagas diseasees_MX
dc.titleMetallothionein-1 and nitric oxide expression are inversely correlated in a murine model of Chagas diseasees_MX
dc.typeArtículoes_MX
dc.type.conacytarticlees_MX
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