Intrapallidal injection of cannabidiol or a selective GPR55 antagonist decreases motor asymmetry and improves fine motor skills in hemiparkinsonian rats

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dc.audiencegeneralPublices_MX
dc.contributor.authorFelipe, Patricio
dc.contributor.authorMorales Davila, Eliud
dc.contributor.authorPatricio Martinez, Aleidy
dc.contributor.authorArana del Carmen, Nayeli
dc.contributor.authorMartínez, Isabel
dc.contributor.authorAguilera, José
dc.contributor.authorPerez Aguilar, Jose Manuel
dc.contributor.authorLimón, Ilhuicamina Daniel
dc.creatorMORALES DAVILA, ELIUD; 784022
dc.creatorPATRICIO MARTINEZ, ALEIDY; 350139
dc.creatorPEREZ AGUILAR, JOSE MANUEL; 516868
dc.date.accessioned2023-02-02T18:37:07Z
dc.date.available2023-02-02T18:37:07Z
dc.date.issued2022-09-02
dc.description.abstract"Cannabidiol (CBD) presents antiparkinsonian properties and neuromodulatory effects, possibly due to the pleiotropic activity caused at multiple molecular targets. Recently, the GPR55 receptor has emerged as a molecular target of CBD. Interestingly, GPR55 mRNA is expressed in the external globus pallidus (GPe) and striatum, hence, it has been suggested that its activity is linked to motor dysfunction in Parkinson’s disease (PD). The present study aimed to evaluate the effect of the intrapallidal injection of both CBD and a selective GPR55 antagonist (CID16020046) on motor asymmetry, fine motor skills, and GAD-67 expression in hemiparkinsonian rats. The hemiparkinsonian animal model applied involved the induction of a lesion in male Wistar rats via the infusion of the neurotoxin 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle via stereotaxic surgery. After a period of twenty days, a second surgical procedure was performed to implant a guide cannula into the GPe".es_MX
dc.identifierhttps://doi.org/10.3389/fphar.2022.945836
dc.identifier.urihttps://hdl.handle.net/20.500.12371/17308
dc.language.isoenges_MX
dc.rights.accesopenAccesses_MX
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0es_MX
dc.subject.otherCannabidiol
dc.subject.otherCID16020046
dc.subject.otherGPR55 receptor
dc.subject.otherBehavioral test
dc.subject.otherMotor asymmetry
dc.subject.otherFine motor skills
dc.subject.otherParkinson's disease
dc.titleIntrapallidal injection of cannabidiol or a selective GPR55 antagonist decreases motor asymmetry and improves fine motor skills in hemiparkinsonian ratses_MX
dc.typeArtículoes_MX
dc.type.conacytarticle
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