The deficiency of myelin in the mutant taiep rat induces a differential immune response related to protection from the human parasite Trichinella spiralis

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dc.audiencegeneralPublices_MX
dc.contributor.authorCortes Sánchez, Ma. del Carmen
dc.contributor.authorEguibar Cuenca, José Ramon
dc.contributor.authorNava Castro, Karen Elizabeth
dc.contributor.authorDel Río Araiza, Víctor Hugo
dc.contributor.authorHernández Bello, Romel
dc.contributor.authorMorales Montor, Jorge
dc.creatorCortes Sánchez, Ma. del Carmen; 0000-0002-9163-2665
dc.creatorEguibar Cuenca, José Ramon, 0000-0001-6594-1141
dc.creatorNava Castro, Karen Elizabeth; 0000-0003-2223-6703
dc.creatorDel Río Araiza, Víctor Hugo; 0000-0002-7868-6407
dc.creatorHernández Bello, Romel; 0000-0002-0744-5948
dc.creatorMorales Montor, Jorge; 0000-0002-9461-610X
dc.date.accessioned2023-03-22T17:26:13Z
dc.date.available2023-03-22T17:26:13Z
dc.date.issued2020-08-20
dc.description.abstract"Taiep rat is a myelin mutant with a progressive motor syndrome characterized by tremor, ataxia, immobility episodes, epilepsy and paralysis of the hindlimbs. The pathology correlated with an increase in nitric oxide activity and lipoperoxidation. In base of the above evidences taiep rat is an appropriate model to study neuroimmune interactions. The aim of this study was to analyze the immune responses in male taiep rats after acute infection with Trichinella spiralis. Our results show that there is an important decrease in the number of intestinal larvae in the taiep rat with respect to Sprague-Dawley control rats. We also found differences in the percentage of innate and adaptive immune cell profile in the mesenteric lymphatic nodes and the spleen that correlated with the demyelination process that took place on taiep subjects. Finally, a clear pro-inflammatory cytokine pattern was seen on infected taiep rats, that could be responsible of the decrement in the number of larvae number. These results sustain the theory that neuroimmune interaction is a fundamental process capable of modulating the immune response, particularly against the parasite Trichinella spiralis in an animal model of progressive demyelination due to tubulinopathy".es_MX
dc.identifierhttps://doi.org/10.1371/journal.pone.0231803
dc.identifier.urihttps://hdl.handle.net/20.500.12371/17892
dc.language.isoenges_MX
dc.rights.accesopenAccesses_MX
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0es_MX
dc.titleThe deficiency of myelin in the mutant taiep rat induces a differential immune response related to protection from the human parasite Trichinella spiralises_MX
dc.typeArtículoes_MX
dc.type.conacytarticlees_MX
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