Sex-specific hypothalamic expression of kisspeptin, gonadotropin releasing hormone, and kisspeptin receptor in progressive demyelination model

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dc.contributor.authorMuñoz de la Torre, Luz Patricia
dc.contributor.authorTrujillo Hernández, Angélica
dc.contributor.authorEguibar, Jose R
dc.contributor.authorCortés, Carmen
dc.contributor.authorMorales Ledesma, Leticia
dc.creatorMuñoz de la Torre, Luz Patricia; 0000-0003-2176-0239
dc.creatorTrujillo Hernández, Angélica; 0000-0002-9931-9294
dc.creatorR Eguibar, Jose R; 0000-0001-6594-1141
dc.date.accessioned2023-02-02T22:35:01Z
dc.date.available2023-02-02T22:35:01Z
dc.date.issued2022-09
dc.description.abstract"Demyelinating diseases, such as multiple sclerosis, decrease the quality of life of patients and can affect reproduction. Assisted reproductive therapies are available, which although effective, aggravate motor symptoms. For this reason, it is important to determine how the control of the hypothalamus-pituitary-gonadal axis is affected in order to develop better strategies for these patients. One way to determine this is using animal models such as the taiep rat, which shows progressive demyelination of the central nervous system, and was used in the present study to characterize the expression of gonadotrophin-releasing hormone (GnRH), Kisspeptin, and kisspeptin receptor (Kiss1R) and luteinizing hormone (LH) secretion. The expression of kisspeptin, GnRH, and Kiss1R was determined at the hypothalamic level by immunofluorescence and serum LH levels were determined by ELISA. The expression of kisspeptin at the hypothalamic level showed sexual dimorphism, where there was an increase in males and a decrease in females during oestrus. There was no change in the expression of GnRH or kisspeptin receptor, regardless of sex. However, a decrease in serum LH concentration was observed in both sexes. The taiep rat showed changes in the expression of kisspeptin at the hypothalamic level".es_MX
dc.identifierhttps://doi.org/10.1016/j.jchemneu.2022.102120
dc.identifier.urihttps://hdl.handle.net/20.500.12371/17337
dc.language.isoenges_MX
dc.rights.accesopenAccesses_MX
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0es_MX
dc.subject.otherDemyelinationes_MX
dc.subject.otherTaiepes_MX
dc.subject.otherKisspeptines_MX
dc.subject.otherLHes_MX
dc.titleSex-specific hypothalamic expression of kisspeptin, gonadotropin releasing hormone, and kisspeptin receptor in progressive demyelination modeles_MX
dc.typeArtículoes_MX
dc.type.conacytarticlees_MX
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