Obese first-degree relatives of patients with type 2 diabetes with elevated triglyceride levels exhibit increased β-cell function

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dc.audiencegeneralPublices_MX
dc.contributor.authorTorres Rasgado, Enrique
dc.contributor.authorPorchia, Leonardo Martín
dc.contributor.authorRuiz Vivanco, Guadalupe
dc.contributor.authorGonzalez Mejia, M Elba
dc.contributor.authorBaez Duarte, Blanca Guadalupe
dc.contributor.authorPulido Pérez, Patricia
dc.contributor.authorRivera, Alicia
dc.contributor.authorRomero, Jose R
dc.contributor.authorPérez Fuentes, Ricardo
dc.creatorTorres Rasgado, Enrique; 0000-0001-5273-4522
dc.creatorPorchia, Leonardo Martín; 0000-0002-4082-7606
dc.creatorRuiz Vivanco, Guadalupe; 0000-0001-5685-3860
dc.creatorBaez Duarte, Blanca Guadalupe; 0000-0002-2311-8605
dc.date.accessioned2023-02-07T17:10:30Z
dc.date.available2023-02-07T17:10:30Z
dc.date.issued2015-02-13
dc.description.abstract"Type 2 diabetes mellitus (T2DM) is characterized as a disease continuum that is marked by metabolic changes that are present for several years, sometimes well before frank diagnosis of T2DM. Genetic predisposition, ethnicity, geography, alterations in BMI, and lipid profile are considered important markers for the pathogenesis of T2DM through mechanisms that remain unresolved and controversial. The aim of this study was to investigate the relationship between triglycerides (TGs) and β-cell function, insulin resistance (IR), and insulin sensitivity (IS) in obese first-degree relatives of patients with T2DM (FDR-T2DM) among subjects from central Mexico with normal glucose tolerance (NGT). Methods: We studied 372 FDR-T2DM subjects (ages,18-65) and determined body mass index (BMI), fasting plasma glucose (FPG), oral glucose tolerance test (OGTT), insulin, and TGs levels. Subjects were categorized based on glycemic control [NGT, prediabetes (PT2DM), or T2DM]. NGT subjects were further categorized by BMI [normal weight (Ob-) or obese (Ob+)] and TGs levels (TG-, <150 mg/dL, or TG+, ≥150 mg/dL). β-cell function, IR, and IS were determined by the homeostasis model assessment of β-cell function (HOMA2-β), homeostasis model assessment of insulin resistance (HOMA2-IR), and Quantitative Insulin Sensitivity Check Index (QUICKI) indices, respectively".es_MX
dc.formatpdfes_MX
dc.identifierhttps://pubmed.ncbi.nlm.nih.gov/25423015/
dc.identifier.urihttps://hdl.handle.net/20.500.12371/17386
dc.language.isoenges_MX
dc.rights.accesopenAccesses_MX
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0es_MX
dc.titleObese first-degree relatives of patients with type 2 diabetes with elevated triglyceride levels exhibit increased β-cell functiones_MX
dc.typeArtículoes_MX
dc.type.conacytarticlees_MX
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