Medical ozone modifies D-dimer, interleukin-6, lactic acid and oxidative stress levels: A possibility for the comprehensive treatment of COVID-19

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dc.audiencecompanieses_MX
dc.audiencestudentses_MX
dc.audienceresearcherses_MX
dc.audienceteacherses_MX
dc.contributor.authorRuíz-García, María Gema
dc.contributor.authorDe la Cruz-Enríquez, Joel
dc.contributor.authorRojas-Morales, Emmanuel
dc.contributor.authorMartínez-Vásquez, Aldrín
dc.contributor.authorTobón-Velasco, Julio César
dc.contributor.authorVázquez-Reyes, Christian Javier
dc.contributor.authorJiménez-Ortega, José Carlos
dc.date.accessioned2022-05-10T07:31:44Z
dc.date.available2022-05-10T07:31:44Z
dc.date.issued2022-05-10
dc.description.abstractBackground: SARS-CoV-2-induced inflammation in COVID-19 is mediated by cytotoxic and pro-oxidant effects that potentiate alveolar, endothelial and immune tissue damage. Objective: We investigated the effect of medicinal ozone administration on the oxidative stress markers; in addition to D-dimer, lactic acid and interleukin-6 as markers of endothelial injury and inflammation process. Methodology: Medicinal ozone with oligo metals was administered in vivo (major autohemotherapy) and in vitro (peripheral blood), to subsequently determine the levels of: H2O2, NO, GPx, CAT, TAP, TBARs, D-dimer, lactic acid and interleukin-6. Results: Medicinal ozone administration with oligo metals induced changes in oxidative stress markers both in vitro and in vivo. The H2O2 and TBARs levels decreased, in turn, NO levels increased (cardiovascular function marker). On the other hand, the levels of the antioxidant enzymes (GPx and CAT) show slightly increase, which indicates an antioxidant enzyme system regulation that counteracts the pro-oxidative effect of the infection. Furthermore, interleukin-6 levels decreased indicating the regulation of the systemic inflammatory process. Finally, lactic acid and D-dimer levels were decreased, establishing an improvement of energy metabolism and endothelial function respectively. Conclusion: The medicinal ozone administration induce decrease in the markers levels of oxidative stress, inflammation and cellular damage, improving the enzymatic antioxidant capacity and cellular metabolism with decrease plaque aggregation that contribute to reducing the risk of vascular endothelial damage. These benefits could be feasible to integrate in the treatment of endothelial injury in COVID-19 patients.es_MX
dc.formatpdfes_MX
dc.identificatorAyTBUAP 7(26):26-41es_MX
dc.identifier.urihttps://hdl.handle.net/20.500.12371/15788
dc.language.isospaes_MX
dc.rights.accesopenAccesses_MX
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0es_MX
dc.subject.classificationMedicina y Ciencias de la Saludes_MX
dc.titleMedical ozone modifies D-dimer, interleukin-6, lactic acid and oxidative stress levels: A possibility for the comprehensive treatment of COVID-19es_MX
dc.typeArtículoes_MX
dc.type.conacytarticlees_MX
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