Metabolic syndrome remodels electrical activity of the sinoatrial node and produces arrhythmias in rats

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dc.audiencegeneralPublices_MX
dc.contributor.authorAlbarado Ibañez, Alondra
dc.contributor.authorAvelino Cruz, José Everardo
dc.contributor.authorVelasco, Myrian
dc.contributor.authorTorres Jácome, Julián
dc.contributor.authorHiriart, Marcia
dc.creatorAlbarado Ibañez, Alondra; 0000-0002-4725-7714
dc.creatorAvelino Cruz, José Everardo; 0000-0001-9685-4710
dc.creatorVelasco, Myrian; 0000-0002-9276-1928
dc.date.accessioned2023-02-02T21:24:56Z
dc.date.available2023-02-02T21:24:56Z
dc.date.issued2013-11-08
dc.description.abstract"In the last ten years, the incidences of metabolic syndrome and supraventricular arrhythmias have greatly increased. The metabolic syndrome is a cluster of alterations, which include obesity, hypertension, hypertriglyceridemia, glucose intolerance and insulin resistance, that increase the risk of developing, among others, atrial and nodal arrhythmias. The aim of this study is to demonstrate that metabolic syndrome induces electrical remodeling of the sinus node and produces arrhythmias. We induced metabolic syndrome in 2-month-old male Wistar rats by administering 20% sucrose in the drinking water. Eight weeks later, the rats were anesthetized and the electrocardiogram was recorded, revealing the presence of arrhythmias only in treated rats. Using conventional microelectrode and voltage clamp techniques, we analyzed the electrical activity of the sinoatrial node. We observed that in the sinoatrial node of “metabolic syndrome rats”, compared to controls, the spontaneous firing of all cells decreased, while the slope of the diastolic depolarization increased only in latent pacemaker cells. Accordingly, the pacemaker currents If and Ist increased. Furthermore, histological analysis showed a large amount of fat surrounding nodal cardiomyocytes and a rise in the sympathetic innervation. Finally, Poincaré plot denoted irregularity in the R-R and P-P ECG intervals, in agreement with the variability of nodal firing potential recorded in metabolic syndrome rats".es_MX
dc.identifierhttps://doi.org/10.1371/journal.pone.0076534
dc.identifier.urihttps://hdl.handle.net/20.500.12371/17328
dc.language.isoenges_MX
dc.rights.accesopenAccesses_MX
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0es_MX
dc.titleMetabolic syndrome remodels electrical activity of the sinoatrial node and produces arrhythmias in ratses_MX
dc.typeArtículoes_MX
dc.type.conacytarticlees_MX
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