Ventricular dysfunction in obese and nonobese rats with metabolic syndrome

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dc.audiencegeneralPublices_MX
dc.contributor.authorTorres Jacome, Julian
dc.contributor.authorOrtiz Fuentes, Brian Sabino
dc.contributor.authorLópez Silva, Benjamin
dc.contributor.authorVelasco, Myrian
dc.contributor.authorIta Amador, Martha Lucia
dc.contributor.authorAlbarado Ibañez, Alondra
dc.creatorTorres Jacome, Julian; 0000-0002-8575-2839
dc.creatorOrtiz Fuentes, Brian Sabino; 0000-0002-3409-897X
dc.creatorAlbarado Ibañez, Alondra; 0000-0002-4725-7714
dc.date.accessioned2023-02-02T20:02:01Z
dc.date.available2023-02-02T20:02:01Z
dc.date.issued2022-02-22
dc.description.abstract"Obesity and dyslipidemias are both signs of metabolic syndrome, usually associated with ventricular arrhythmias. Here, we tried to identify cardiac electrical alteration and biomarkers in nonobese rats with metabolic syndrome (MetS), and these findings might lead to more lethal arrhythmias than obese animals. The MetS model was developed in Wistar rats with high-sucrose diet (20%), and after twenty-eight weeks were obtained two subgroups: obese (OMetS) and nonobese (NOMetS). The electrocardiogram was used to measure the ventricular arrhythmias and changes in the heart rate variability. Also, we measured ventricular hypertrophy and its relationship with electrical activity alterations of both ventricles, using micro-electrode and voltage clamp techniques. Also, we observed alterations in the contraction force of ventricles where a transducer was used to record mechanical and electrical papillary muscle, simultaneously. Despite both subgroups presenting long QT syndrome (0.66 ± 0.05 and 0.66 ± 0.07 ms with respect to the control 0.55 ± 0.1 ms), the changes in the heart rate variability were present only in OMetS, while the NOMetS subgroup presented changes in QT interval variability (NOMetS SD = 1.8, SD2 = 2.8; SD1/SD2 = 0.75)".es_MX
dc.identifierhttps://pubmed.ncbi.nlm.nih.gov/35242881/
dc.identifier.urihttps://hdl.handle.net/20.500.12371/17322
dc.language.isoenges_MX
dc.rights.accesopenAccesses_MX
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0es_MX
dc.titleVentricular dysfunction in obese and nonobese rats with metabolic syndromees_MX
dc.typeArtículoes_MX
dc.type.conacytarticle
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