Multiple effects of 4-aminopyridine on feline and rabbit sinoatrial node myocytes and multicellular preparations

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dc.audiencegeneralPublices_MX
dc.contributor.authorAréchiga Figueroa, Iván Arael
dc.contributor.authorRodríguez Martínez, Martin
dc.contributor.authorAlbarado Ibañez, Alondra
dc.contributor.authorTorres Jácome, Julián
dc.contributor.authorSánchez Chapula, José A
dc.creatorAréchiga Figueroa, Iván Arael; 0000-0003-3124-7148
dc.creatorAlbarado Ibañez, Alondra; 0000-0002-4725-7714
dc.creatorTorres Jacome, Julian; 0000-0002-8575-2839
dc.date.accessioned2023-02-02T21:32:10Z
dc.date.available2023-02-02T21:32:10Z
dc.date.issued2009-09-18
dc.description.abstract"4-aminopyridine (4-AP) is commonly used to block the transient outward potassium current, I(to), in cardiac and noncardiac tissues. In the present work, we found that 4-AP inhibited the rapid component of the delayed rectifier potassium current, I(Kr), in rabbit-isolated sinoatrial node myocytes by 25% (1 mM) and 51% (5 mM) and inhibited the slow component of the delayed rectifier potassium current, I(Ks), in cat- isolated sinoatrial node myocytes by 39% (1 mM) and 62% (5 mM). In cat- and rabbit-isolated sinoatrial node myocytes, 4-AP activated muscarinic receptors in a voltage-dependent manner to increase the acetylcholine-activated potassium current, I(KACh). In multicellular preparations of the central region of the sinoatrial node from nonreserpinized rabbits, 4-AP produced an increase in action potential overshoot, frequency, and rate of diastolic depolarization. In the presence of the beta-adrenergic antagonist propranolol, 4-AP produced a marked increase in duration and a marked decrease in maximum diastolic potential and eventually, cessation of the spontaneous activity in preparations from the sinoatrial central region. In multicellular preparations from reserpinized rabbits, 4-AP produced similar effects to those observed in the presence of propranolol. We conclude that 4-AP inhibits multiple cardiac K(+) currents, including I(to), I(Kr), and I(Ks), and that these activities mask I(KACh) activation".es_MX
dc.identifierhttps://pubmed.ncbi.nlm.nih.gov/19763605/
dc.identifier.urihttps://hdl.handle.net/20.500.12371/17329
dc.language.isoenges_MX
dc.rights.accesopenAccesses_MX
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0es_MX
dc.subjectModelos animales en investigación
dc.subjectPotasio en el cuerpo
dc.subjectCanales de potasio
dc.subjectPotasio--Transporte fisiológico
dc.subjectReceptores muscarínicos
dc.titleMultiple effects of 4-aminopyridine on feline and rabbit sinoatrial node myocytes and multicellular preparationses_MX
dc.typeArtículoes_MX
dc.type.conacytarticlees_MX
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