Browsing by Author "Torres Jácome, Julián"
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Artículo Heart rate variability as early biomarker for the evaluation of diabetes mellitus progress(2016-04-14) Arroyo Carmona, Rosa Elena; López Serrano, Ana Laura; Albarado Ibañez, Alondra; Mendoza Lucero, Francisca María Fabiola; Medel Cajica, David; López Mayorga, Ruth Mery; Torres Jácome, Julián; Arroyo Carmona, Rosa Elena; 0000-0002-0471-994X; Albarado Ibañez, Alondra; 0000-0002-4725-7714; Mendoza Lucero, Francisca María Fabiola; 0000-0001-6368-265X"According to the American Diabetes Association (ADA), the side effects of diabetes mellitus have recently increased the global health expenditure each year. Of these, the early diagnostic can contribute to the decrease on renal, cardiovascular, and nervous systems complications. However, the diagnostic criteria, which are commonly used, do not suggest the diabetes progress in the patient. In this study, the streptozotocin model in mice (cDM) was used as early diagnostic criterion to reduce the side effects related to the illness. The results showed some clinical signs similarly to five-year diabetes progress without renal injury, neuropathies, and cardiac neuropathy autonomic in the cDM-model. On the other hand, the electrocardiogram was used to determine alterations in heart rate and heart rate variability (HRV), using the Poincaré plot to quantify the HRV decrease in the cDM-model. Additionally, the SD1/SD2 ratio and ventricular arrhythmias showed increase without side effects of diabetes. Therefore, the use of HRV as an early biomarker contributes to evaluating diabetes mellitus complications from the diagnostic".Artículo Metabolic syndrome remodels electrical activity of the sinoatrial node and produces arrhythmias in rats(2013-11-08) Albarado Ibañez, Alondra; Avelino Cruz, José Everardo; Velasco, Myrian; Torres Jácome, Julián; Hiriart, Marcia; Albarado Ibañez, Alondra; 0000-0002-4725-7714; Avelino Cruz, José Everardo; 0000-0001-9685-4710; Velasco, Myrian; 0000-0002-9276-1928"In the last ten years, the incidences of metabolic syndrome and supraventricular arrhythmias have greatly increased. The metabolic syndrome is a cluster of alterations, which include obesity, hypertension, hypertriglyceridemia, glucose intolerance and insulin resistance, that increase the risk of developing, among others, atrial and nodal arrhythmias. The aim of this study is to demonstrate that metabolic syndrome induces electrical remodeling of the sinus node and produces arrhythmias. We induced metabolic syndrome in 2-month-old male Wistar rats by administering 20% sucrose in the drinking water. Eight weeks later, the rats were anesthetized and the electrocardiogram was recorded, revealing the presence of arrhythmias only in treated rats. Using conventional microelectrode and voltage clamp techniques, we analyzed the electrical activity of the sinoatrial node. We observed that in the sinoatrial node of “metabolic syndrome rats”, compared to controls, the spontaneous firing of all cells decreased, while the slope of the diastolic depolarization increased only in latent pacemaker cells. Accordingly, the pacemaker currents If and Ist increased. Furthermore, histological analysis showed a large amount of fat surrounding nodal cardiomyocytes and a rise in the sympathetic innervation. Finally, Poincaré plot denoted irregularity in the R-R and P-P ECG intervals, in agreement with the variability of nodal firing potential recorded in metabolic syndrome rats".Artículo Multiple effects of 4-aminopyridine on feline and rabbit sinoatrial node myocytes and multicellular preparations(2009-09-18) Aréchiga Figueroa, Iván Arael; Rodríguez Martínez, Martin; Albarado Ibañez, Alondra; Torres Jácome, Julián; Sánchez Chapula, José A; Aréchiga Figueroa, Iván Arael; 0000-0003-3124-7148; Albarado Ibañez, Alondra; 0000-0002-4725-7714; Torres Jacome, Julian; 0000-0002-8575-2839"4-aminopyridine (4-AP) is commonly used to block the transient outward potassium current, I(to), in cardiac and noncardiac tissues. In the present work, we found that 4-AP inhibited the rapid component of the delayed rectifier potassium current, I(Kr), in rabbit-isolated sinoatrial node myocytes by 25% (1 mM) and 51% (5 mM) and inhibited the slow component of the delayed rectifier potassium current, I(Ks), in cat- isolated sinoatrial node myocytes by 39% (1 mM) and 62% (5 mM). In cat- and rabbit-isolated sinoatrial node myocytes, 4-AP activated muscarinic receptors in a voltage-dependent manner to increase the acetylcholine-activated potassium current, I(KACh). In multicellular preparations of the central region of the sinoatrial node from nonreserpinized rabbits, 4-AP produced an increase in action potential overshoot, frequency, and rate of diastolic depolarization. In the presence of the beta-adrenergic antagonist propranolol, 4-AP produced a marked increase in duration and a marked decrease in maximum diastolic potential and eventually, cessation of the spontaneous activity in preparations from the sinoatrial central region. In multicellular preparations from reserpinized rabbits, 4-AP produced similar effects to those observed in the presence of propranolol. We conclude that 4-AP inhibits multiple cardiac K(+) currents, including I(to), I(Kr), and I(Ks), and that these activities mask I(KACh) activation".Artículo Seguimiento farmacoterapéutico de antiparasitarios para pacientes pediátricos de Santa María Acuexcomac-México(2005-07) Gutiérrez Godínez, Jéssica; Torres Jácome, Julián; Herrera, Emma V.; Albarado Ibañez, Alondra; Ponce, Daniela; López López, J. Gustavo; Torres Jacome, Julian; 0000-0002-8575-2839; Albarado Ibañez, Alondra; 0000-0002-4725-7714"El Método Dáder para el seguimiento farmacoterapéutico ha sido una herramienta que permite detectar y solucionar problemas relacionados con la medicación y puede adaptarse a las condiciones de la población mexicana que vive en comunidades rurales. El programa se ofreció a 300 infantes de la comunidad de Santa María Acuexcomac, de los cuales solo 102 aceptaron participar. En la primera etapa se diagnosticaron 62 casos de parasitosis causada por Entamoeba histolytica, Himenolepis nana y/o Giardia lamblia. Se prescribieron quinfamida para los casos de amibiasis, albendazol para himenolepiasis y giardiasis, o ambos medicamentos para amibiasis en conjunción con himenolepiasis y/o giardiasis. Al finalizar esta etapa la adherencia al tratamiento farmacoterapeutico de los pacientes que se les realizo el seguimiento farmacoterapéutico fue en promedio de 96.9%, mientras que 76 % de estos pacientes no presentaron parasitosis en un segundo análisis coproparasitoscópico. En la segunda etapa se administró metronidazol para el tratamiento de amibiasis y/o giardiasis, y prazicuantel para el tratamiento de himenolepiasis. A todos los pacientes se les realizó el seguimiento farmacoterapéutico obteniéndose una adherencia del 81.8%. Al finalizar el programa ninguno de los pacientes a los cuales se les brindo el seguimiento farmacoterapéutico, presentaron parasitosis".Artículo The role of the autonomic nervous system on cardiac rhythm during the evolution of diabetes mellitus using heart rate variability as a biomarker(2019-05-09) Albarado Ibañez, Alondra; Arroyo Carmona, Rosa Elena; Sánchez Hernández, Rommel; Ramos Ortiz, Geovanni; Frank, Alejandro; García Gudiño, David; Torres Jácome, Julián; Albarado Ibañez, Alondra; 0000-0002-4725-7714; Arroyo Carmona, Rosa Elena; 0000-0002-0471-994X; Sánchez Hernández, Rommel; 0000-0002-4008-4179"Heart rate variability (HRV) is highly influenced by the Autonomic Nervous System (ANS). Several illnesses have been associated with changes in the ANS, thus altering the pattern of HRV. However, the variability of the heart rhythm is originated within the Sinus Atrial Node (SAN) which has its own variability. Still, although both oscillators produce HRV, the influence of the SAN on HRV has not yet been exhaustively studied. On the other hand, the complications of diabetes mellitus (DM), for instance, nephropathy, retinopathy, and neuropathy, increase cardiovascular morbidity and mortality. Traditionally, these complications are diagnosed only when the patient is already suffering from the negative symptoms these complications implicate. Consequently, it is of paramount importance to develop new techniques for early diagnosis prior to any deterioration on healthy patients. HRV has been proved to be a valuable, noninvasive clinical evidence for evaluating diseases and even for describing aging and behavior. In this study, several ECGs were recorded and their RR and PP intervals were analyzed to detect the interpotential interval (ii) of the SAN. Additionally, HRV reduction was quantified to identify alterations in the nervous system within the nodal tissue via measuring the SD1/SD2 ratio in a Poincaré plot".