Impact of Non-Surgical Periodontal Treatment on the Concentration and Level of MRP-8/14 (Calprotectin) as an Inflammatory Biomarker in Women with Periodontitis and Rheumatoid Arthritis: A Quasi-Experimental Study
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2024-01-01
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Abstract
"According to the Global Burden of Disease Study 2017, periodontal disease, a chronic inflammatory disease, is considered the 11th most prevalent condition. It affects tooth-supporting tissues and has effects ranging from gingivitis to the most aggressive forms of periodontitis (PE) that result in tooth loss . Following caries, PE is considered the second-most-frequent oral disease. On a global scale, the prevalence of severe periodontal disease has experienced a progressive increase, despite ongoing attempts to prevent and manage the advancement of this condition, and gingivitis and periodontitis now have a global prevalence ranging from 20% to 50%. Periodontal disease affects the tissues that both surround and support the teeth. The disease is characterized by bleeding or swollen gums (gingivitis), pain, and sometimes bad breath. In its more severe form, the gum can come away from the tooth and supporting bone, causing teeth to become loose and sometimes fall out. The main risk factors for periodontal disease are poor oral hygiene and tobacco use. The origin of periodontitis is multifactorial and involves multiple component causes, genetics, epigenetic influences, and modifiable factors such as environmental factors, habits, and medications that establish and propagate periodontitis lesions. The appearance of dysbiosis of the subgingival microbiome triggers an inflammatory response. The aim of this study was to evaluate the impact of non-surgical periodontal treatment (NS-PT) on periodontal parameters and inflammatory biomarkers in the concentration and level of calprotectin (CLP) in women with periodontitis and rheumatoid arthritis (RA)".