Browsing by Author "Baez Duarte, Blanca Guadalupe"

Now showing 1 - 13 of 13
  • Artículo
    Association of interleukin-6 haplotypes, obesity, and metabolic abnormalities in a population of central Mexico
    (2010-10-01) Zamora Ginez, Irma Del Carmen; Sánchez Guillén, Maria del Carmen; Pérez Fuentes, Ricardo; Baez Duarte, Blanca Guadalupe; Brambila, Eduardo; García Zapién, Alejandra; Mendoza Carrera, Francisco; Zamora Ginez, Irma Del Carmen; 0000-0003-0403-2969; Pérez Fuentes, Ricardo; 0000-0002-9104-1427; Baez Duarte, Blanca Guadalupe; 0000-0002-2311-8605; Brambila, Eduardo; 0000-0003-0377-0943; Mendoza Carrera, Francisco; 0000-0002-0786-988X
    "We undertook this study to determine the relationship among -174G>C and 598G>A polymorphisms in the promoter region of interleukin-6, obesity, and metabolic abnormalities in subjects from central Mexico".
  • Artículo
    Beta-cell function is associated with metabolic syndrome in Mexican subjects
    (2010-08-30) Baez Duarte, Blanca Guadalupe; Sánchez Guillén, María Del Carmen; Fuentes, Pérez; Zamora Ginez, Irma Del Carmen; Leon Chavez, Bertha Alicia; Revilla Monsalve, Cristina; Islas Andrade, Sergio; Baez Duarte, Blanca Guadalupe; 0000-0002-2311-8605; Zamora Ginez, Irma Del Carmen; 0000-0003-0403-2969; Leon Chavez, Bertha Alicia; 0000-0002-8041-9404
    "Aims: The clinical diagnosis of metabolic syndrome does not find any parameters to evaluate the insulin sensitivity (IS) or β-cell function. The evaluation of these parameters would detect early risk of developing metabolic syndrome. The aim of this study is to determine the relationship between β-cell function and presence of metabolic syndrome in Mexican subjects".
  • Artículo
    Dry eye disease association with computer exposure time among subjects with computer vision syndrome
    (2020-12-08) Sánchez Valerio, María del Rosario; Mohamed Noriega, Karim; Zamora Ginez, Irma; Baez Duarte, Blanca Guadalupe; Vallejo Ruiz, Verónica; Sánchez Valerio, María del Rosario; 0000-0003-0231-9915; Mohamed Noriega, Karim; 0000-0001-8252-5924; Zamora Ginez, Irma; 0000-0003-0403-2969; Baez Duarte, Blanca Guadalupe; 0000-0002-2311-8605; Vallejo Ruiz, Verónica; 0000-0001-7884-1406
    "Purpose: To assess the time of exposure to the computer and dry eye disease (DED) in subjects with computer vision syndrome (CVS). Methods: A cross-sectional study was conducted in office workers, computer users of both sexes, with an age range of 18-45 years without comorbidities; we included 108 subjects divided into 3 groups according to the time of computer exposure in hours per day (H/D): <4 (n = 23), 4 -7.9 (n = 49), >8 (n = 39). A specific questionnaire was applied to them on the exposure time and the type of visual display terminal (VDT) used, as well as the computer vision symptoms scale (CVSS17). DED was diagnosed with the Ocular Surface Disease Index (OSDI). Ocular surface damage and signs of DED were evaluated with the tear rupture time test (TBUT), the integrity of the ocular surface by ocular surface staining (OSS) and the production of the aqueous basal tear film using the Schirmer test".
  • Artículo
    Factores de mayor influencia en el riesgo cardiovascular y su relación con magnesio sérico y su ingesta
    (2022-02-22) García Aragón, Karla H.; Zamora Ginez, Irma; Baez Duarte, Blanca Guadalupe; Castañeda Roldán, Elsa I.; Linares Fleites, Gladys; Nieva Vázquez, Adriana; Meneses Zamora, Paola; Pesqueda Cendejas, Lady K.; Flores Martínez, Nayelli; Bautista Pot, Zayra I.; Zamora Ginez, Irma; 0000-0003-0403-2969; Baez Duarte, Blanca Guadalupe; 0000-0002-2311-8605; Linares Fleites, Gladys; 0000-0003-0856-3994
    "En este estudio se caracterizaron 66 sujetos clínica-antropométrica y bioquímicamente. Los factores con mayor influencia identificados fueron: triglicéridos (TG), lipoproteínas de muy baja densidad (VLDL), lipoproteínas de baja densidad (LDL) y colesterol total (CT); Mg sérico (MgS) correlacionó con TG (Rho = 0.270, p = 0.028), CT (Rho = 0.349, p = 0.004), LDL (Rho = 0.251, p = 0.042) y VLDL (Rho = 0.270, p = 0.028), MgS correlacionó con CT ajustado para índice de masa corporal (IMC), glucosa y edad (Rho = 0.303, p = 0.016). Los sujetos sin antecedentes familiares de enfermedad cardiovascular (AF_ECV) presentaron mayor ingesta de Mg (p = 0.023) que aquellos con AF_ECV y los hombres tuvieron mayor ingesta de Mg que las mujeres (p = 0.005). En conclusión, los factores de mayor influencia en el riesgo CV son TG, LDL, VLDL y CT, los cuales correlacionan positiva y significativamente con MgS, CT aún ajustado para IMC, glucosa y edad; además la ingesta de magnesio es mayor en sujetos sin AF_ECV y en los hombres".
  • Artículo
    Identification of anthropometric indices that best correlate with insulin sensitivity and insulin resistance from subjects from central Mexico
    (2014) Porchia, Leonardo Martín; Gonzalez Mejia, Martha Elba; Torres Rasgado, Enrique; Ruiz Vivanco, Guadalupe; Baez Duarte, Blanca Guadalupe; Pulido Pérez, Patricia; Pérez Fuentes, Ricardo; Porchia, Leonardo Martín; 0000-0002-4082-7606; Gonzalez Mejia, Martha Elba; 0000-0003-2569-1998; Torres Rasgado, Enrique; 0000-0001-5273-4522; Baez Duarte, Blanca Guadalupe; 0000-0002-2311-8605
    "Insulin Sensitivity (IS) and Insulin Resistance (IR) mark the development of Type 2 Diabetes. Many reports have demonstrated that anthropometric indices can detect IS and IR, however ethnic variations can influence the optimal cutoff value. Therefore, the aim of this study was to determine the optimal cutoff value for Waist Circumference (WC), Body-Mass Index (BMI), Waist-To-Hip Ratio (WHR), Waist-To-Height Ratio (WHtR), and percent Body Fat (BF %) to determine IS and IR from subjects from central Mexico. Methods: WC, BMI, WHR, WHtR, BF%, fasting plasma glucose, and insulin were determined in 569 subjects (male=286 & females=283; ages: 18-84). IR and IS were determined by the Homeostatic Model Assessment online calculator and Quantitative Insulin Sensitivity Check Index, respectively. The area under the Receiver Operating Characteristic curve (AUC) and Youden´s index for each anthropometric index was calculated to determine its cutoff value. Cutoff value´s efficiency was measured by determining the test´s accuracy".
  • Artículo
    Índice TG/HDL para identificar a sujetos con síndrome metabólico en población mexicana
    (2022-09) Baez Duarte, Blanca Guadalupe; Zamora Ginez, Irma; Rodríguez Ramíre, Saúl O.; Pesqueda Cendejas, Lady K.; García Aragón, Karla H.; Baez Duarte, Blanca Guadalupe; 0000-0002-2311-8605; Zamora Ginez, Irma; 0000-0003-0403-2969
    "El índice triglicéridos/lipoproteína de alta densidad (TG/HDL) ha sido propuesto como un indicador de riesgo cardiovascular. En México, existe un estudio en adultos jóvenes que lo relaciona con resistencia a la insulina, pero no se ha definido un punto de corte que distinga a sujetos con síndrome metabólico. Objetivo: Determinar el punto de corte para el índice TG/HDL que identifique a sujetos con síndrome metabólico en población mexicana".
  • Artículo
    Metallothionein-1 and nitric oxide expression are inversely correlated in a murine model of Chagas disease
    (2014-04) Gonzalez Mejia, Martha Elba; Torres Rasgado, Enrique; Porchia, Leonardo Martín; Rosas Salgado, Hilda; Totolhua, José Luis; Ortega, Arturo; Hernández Kelly, Luisa Clara Regina; Ruiz Vivanco, Guadalupe; Baez Duarte, Blanca Guadalupe; Pérez Fuentes, Ricardo; Gonzalez Mejia, Martha Elba; 0000-0003-2569-1998; Torres Rasgado, Enrique; 0000-0001-5273-4522; Porchia, Leonardo Martín; 0000-0002-4082-7606; Baez Duarte, Blanca Guadalupe; 0000-0002-2311-8605
    "Chagas disease, caused by Trypanosoma cruzi, represents an endemic among Latin America countries. The participation of free radicals, especially nitric oxide (NO), has been demonstrated in the pathophysiology of seropositive individuals with T. cruzi. In Chagas disease, increased NO contributes to the development of cardiomyopathy and megacolon. Metallothioneins (MTs) are efficient free radicals scavengers of NO in vitro and in vivo. Here, we developed a murine model of the chronic phase of Chagas disease using endemic T. cruzi RyCH1 in BALB/c mice, which were divided into four groups: infected non-treated (Inf), infected N-monomethyl-L-arginine treated (Inf L-NAME), non-infected L-NAME treated and non-infected vehicle-treated. We determined blood parasitaemia and NO levels, the extent of parasite nests in tissues and liver MT-I expression levels. It was observed that NO levels were increasing in Inf mice in a time-dependent manner. Inf L-NAME mice had fewer T. cruzi nests in cardiac and skeletal muscle with decreased blood NO levels at day 135 post infection. This affect was negatively correlated with an increase of MT-I expression (r = -0.8462, p < 0.0001). In conclusion, we determined that in Chagas disease, an unknown inhibitory mechanism reduces MT-I expression, allowing augmented NO levels".
  • Artículo
    Obese first-degree relatives of patients with type 2 diabetes with elevated triglyceride levels exhibit increased β-cell function
    (2015-02-13) Torres Rasgado, Enrique; Porchia, Leonardo Martín; Ruiz Vivanco, Guadalupe; Gonzalez Mejia, M Elba; Baez Duarte, Blanca Guadalupe; Pulido Pérez, Patricia; Rivera, Alicia; Romero, Jose R; Pérez Fuentes, Ricardo; Torres Rasgado, Enrique; 0000-0001-5273-4522; Porchia, Leonardo Martín; 0000-0002-4082-7606; Ruiz Vivanco, Guadalupe; 0000-0001-5685-3860; Baez Duarte, Blanca Guadalupe; 0000-0002-2311-8605
    "Type 2 diabetes mellitus (T2DM) is characterized as a disease continuum that is marked by metabolic changes that are present for several years, sometimes well before frank diagnosis of T2DM. Genetic predisposition, ethnicity, geography, alterations in BMI, and lipid profile are considered important markers for the pathogenesis of T2DM through mechanisms that remain unresolved and controversial. The aim of this study was to investigate the relationship between triglycerides (TGs) and β-cell function, insulin resistance (IR), and insulin sensitivity (IS) in obese first-degree relatives of patients with T2DM (FDR-T2DM) among subjects from central Mexico with normal glucose tolerance (NGT). Methods: We studied 372 FDR-T2DM subjects (ages,18-65) and determined body mass index (BMI), fasting plasma glucose (FPG), oral glucose tolerance test (OGTT), insulin, and TGs levels. Subjects were categorized based on glycemic control [NGT, prediabetes (PT2DM), or T2DM]. NGT subjects were further categorized by BMI [normal weight (Ob-) or obese (Ob+)] and TGs levels (TG-, <150 mg/dL, or TG+, ≥150 mg/dL). β-cell function, IR, and IS were determined by the homeostasis model assessment of β-cell function (HOMA2-β), homeostasis model assessment of insulin resistance (HOMA2-IR), and Quantitative Insulin Sensitivity Check Index (QUICKI) indices, respectively".
  • Artículo
    Regulación de la ingesta de alimento: una aproximación al sistema endocannabinoide
    (2015) Cortés Romero, Celso Enrique; Baez Duarte, Blanca Guadalupe; Zamora Ginez, Irma; Bilbao Reboredo, Tania; Cebada Ruiz, Jorge; Galicia, Salvador; Vélez Pliego, Marcela; Cortés Romero, Celso Enrique; 0000-0002-8891-0505; Baez Duarte, Blanca Guadalupe; 0000-0002-2311-8605; Zamora Ginez, Irma; 0000-0003-0403-2969
    "El sobrepeso y la obesidad son un problema de salud mundial y su prevalencia continúa en aumento. Se calcula que son 300 millones de adultos obesos y 4 veces más tienen sobrepeso. El panorama para la población infantil tampoco es alentador, si consideramos que 43 millones de niños menores a 5 años son obesos o tienen sobrepeso. La acumulación de grasa corporal puede deberse a un desequilibrio en la compleja interacción de señales químicas entre el sistema nervioso central y tejidos periféricos encargados del control de la conducta alimentaria. Diversos estudios sugieren la participación del sistema endocannabinoide como un regulador clave de la ingesta de alimento. La inhibición farmacológica de los receptores CB1 y la regulación de su expresión a través de la dieta tienen un gran potencial como alternativa para el tratamiento de alteraciones de la conducta alimentaria y de uno de los trastornos más prevalentes, el síndrome metabólico".
  • Artículo
    Relación entre el índice lipoproteínas de baja densidad (LDL)/lipoproteínas de alta densidad (HDL) con enzimas antioxidantes y el índice oxLDL/HDL
    (2019-02-21) Zamora Ginez, Irma; Baez Duarte, Blanca Guadalupe; Nieva Vázquez, Adriana; García Aragón, Karla Hilsen; Monjaraz Guzmán, Eduardo; Mendoza Carrera, Francisco; Meneses Zamora, Paola; Flores Blanco, Claudia Valeria; Luna de Jesús, Karina; Zamora Ginez, Irma; 0000-0003-0403-2969; Baez Duarte, Blanca Guadalupe; 0000-0002-2311-8605; Nieva Vazquez, Adriana; 0000-0001-8435-0734; García Aragón, Karla Hilsen; 0000-0001-7737-6629
    "El índice de lipoproteínas de baja densidad (LDL)/lipoproteínas de alta densidad (HDL) es un factor predictivo de aterosclerosis, la cual está asociada con modificaciones oxidativas Objetivo: Evaluar la asociación del índice con marcadores de estrés oxidativo Método: Se incluyeron 444 sujetos, caracterizados clínica, antropométrica y bioquímicamente; se cuantificó superóxido dismutasa, glutation peroxidasa 3 (GPx3), magnesio e índice LDL oxidadas (oxLDL/HDL) Resultados: La disminución en 1.014 unidades del índice LDL/HDL se asoció con aumento de 1 unidad/mL de superóxido dismutasa (p = 0.030) y la de 0.023 unidades con aumento de 1 nmol/minuto/mL de GPx3 (p < 0.0005). El aumento en 1 unidad del índice se asoció con aumento de 0.831 unidades en el índice oxLDL/HDL (p < 0.05). Después de controlar el efecto del sexo, edad, fumar, obesidad y resistencia a la insulina, la reducción de 0.001 por unidad del índice se asoció con aumento de 1 µg/g de magnesio en uñas (p = 0.020)".
  • Artículo
    Relationship of triglycerides/high density lipoprotein-cholesterol index with antioxidant defense and outstanding association with high sensitive C-reactive protein in Mexican subjects
    (2018-04) Baez Duarte, Blanca Guadalupe; Ríos Fuentes, J.C; Zamora Ginez, Irma Del Carmen; Mendoza Carrera, Francisco; Briones Rojas, R.; Baez Duarte, Blanca Guadalupe; 0000-0002-2311-8605; Zamora Ginez, Irma Del Carmen; 0000-0003-0403-2969; Mendoza Carrera, Francisco; 0000-0002-0786-988X
    "Background: The TriGlycerides/High-Density Lipoprotein- Cholesterol (TG/HDL-C) ratio is a new index that has been proposed to estimate CardioVascular Risk (CVR). However, the relationship between this index with the antioxidant defense and inflammation is unknown. The aim of the study was to determine the relationship between the TG/HDL-C index with antioxidant defense and inflammation marker in Mexican subjects".
  • Artículo
    Sensibilidad a la insulina y síndrome metabólico
    (2014-06) Zamora Ginez, Irma Del Carmen; Baez Duarte, Blanca Guadalupe; Cortés Romer, Celso; Bilbao Reboredo, Tania; Cebada Ruíz, Jorge; Galicia, Salvador; Vèlez Pliego, Marcela; Zamora Ginez, Irma Del Carmen; 0000-0003-0403-2969; Baez Duarte, Blanca Guadalupe; 0000-0002-2311-8605; Galicia, Salvador; 0000-0001-9350-7983; Vèlez Pliego, Marcela; 0000-0003-4629-1838
    "El Síndrome Metabólico (SM) es considerado un problema de salud pública a nivel mundial. La Diabetes tipo 2 (DT2) y las enfermedades cardiovasculares son dos de las complicaciones del SM que se encuentran dentro de las principales causas de muerte de la población en edad productiva. La comprensión de los mecanismos responsables del inicio y desarrollo del SM permitirá el diagnóstico temprano y el diseño de estrategias de prevención de las complicaciones. Se ha sugerido recientemente que el origen del SM es en realidad la consecuencia de la interacción entre los defectos en la sensibilidad a la insulina y la función de la célula-β del páncreas endocrino, lo que, a su vez, es un factor condicionante para el desarrollo de las alteraciones metabólicas propias de este síndrome".
  • Artículo
    Triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) index as a reference criterion of risk for metabolic syndrome (MetS) and low insulin sensitivity in apparently healthy subjects
    (2017) Baez Duarte, Blanca Guadalupe; Zamora Ginez, Irma; González Duarte, Ramiro; Torres Rasgado, Enrique; Ruiz Vivanco, Guadalupe; Pérez Fuentes, Ricardo; Baez Duarte, Blanca Guadalupe; 0000-0002-2311-8605; Zamora Ginez, Irma; 0000-0003-0403-2969; González Duarte, Ramiro; 0000-0002-6041-9888
    "Aim: To evaluate if the TG/HDL-C index can be considered as a reference criterion of MetS and low insulin sensitivity in apparently healthy subjects. Methods: The subjects were Mexican mestizos who resided in Puebla City, Mexico, who were anthropometrically, biochemically, and clinically characterized. The TG/HDL-C index was calculated by dividing triglyceride (TG) levels by HDL-C levels. MetS was diagnosed by the Third Report from the Adult Treatment Panel-National Cholesterol Education Program (ATP-III NCEP) criteria, while insulin sensitivity was evaluated by the Quantitative Insulin sensitivity Check Index (QUICKI). Results: The study included 813 subjects, with an average age of 38.6 ± 12.1 years, of which 564 were women and 249 men. An association was found between high TG/HDL-C index and low insulin sensitivity (Odds ratio [OR]: 4.09; p < 0.01) and with MetS (OR: 15.29; p < 0.01). A correlation was found between the TG/HDL-C index and QUICKI (rho: –0.4989; p < 0.01) and with MetS (rho: 0.6581; p < 0.01). Conclusion: The results indicate that the TG/HDL-C index is associated with low insulin sensitivity and MetS in apparently healthy subjects, suggesting this index as a reference criterion of risk for low insulin sensitivity and MetS".